تداخل‌های دارویی
Cefazolin + Kanamycin
شدت: متوسط
Cefazolin and Kanamycin: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cefazolin given with an aminoglycoside such as kanamycin has been associated with a possible additive risk of kidney injury, and aminoglycosides also carry ototoxic risk. Kanamycin is itself markedly nephrotoxic and ototoxic, so any added renal impairment raises aminoglycoside exposure and toxicity.
معنای این تداخل به زبان ساده
Cefazolin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
چرا رخ می‌دهد
Additive nephrotoxic potential, with reduced renal clearance of the aminoglycoside if kidney function declines.
اقدام لازم
Monitor serum creatinine and urine output and aminoglycoside levels where applicable during combined use. Adjust the kanamycin dose to renal function and watch for hearing or vestibular symptoms.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cefazolin و Kanamycin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cefazolin
پرسش‌های متداول
Can I take Cefazolin with Kanamycin?
MediHelp rates the interaction as moderate. Cefazolin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefazolin given with an aminoglycoside such as kanamycin has been associated with a possible additive risk of kidney injury, and aminoglycosides also carry ototoxic risk. Kanamycin is itself markedly nephrotoxic and ototoxic, so any added renal impairment raises aminoglycoside exposure and toxicity.
How serious is the interaction between Cefazolin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output and aminoglycoside levels where applicable during combined use. Adjust the kanamycin dose to renal function and watch for hearing or vestibular symptoms.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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