تداخل‌های دارویی
Amikacin + Cefepime
شدت: متوسط
Amikacin and Cefepime: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both are given intravenously and both can affect the kidney, and amikacin also carries ototoxicity risk. Cefepime is not strongly nephrotoxic, but accumulation of cefepime in renal impairment raises neurotoxicity risk, and amikacin toxicity also rises when renal function declines.
معنای این تداخل به زبان ساده
Amikacin and Cefepime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefepime belongs to Anti Bacterial.
چرا رخ می‌دهد
Possible additive renal effects; both drugs are renally cleared, so declining renal function raises exposure to each.
اقدام لازم
Monitor serum creatinine and amikacin levels, and adjust the doses of both drugs to renal function. Watch for confusion or myoclonus from cefepime accumulation and for hearing changes.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amikacin و Cefepime، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cefepime
- Cefepime + Cholera vaccine متوسط
- Cefepime + Dexamethasone-tobramycin متوسط
- Cefepime + Gentamicin متوسط
- Cefepime + Kanamycin متوسط
- Cefepime + Microbiota متوسط
- Cefepime + Plazomicin متوسط
تداخلات دیگر Amikacin
پرسش‌های متداول
Can I take Amikacin with Cefepime?
MediHelp rates the interaction as moderate. Amikacin and Cefepime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are given intravenously and both can affect the kidney, and amikacin also carries ototoxicity risk. Cefepime is not strongly nephrotoxic, but accumulation of cefepime in renal impairment raises neurotoxicity risk, and amikacin toxicity also rises when renal function declines.
How serious is the interaction between Amikacin and Cefepime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels, and adjust the doses of both drugs to renal function. Watch for confusion or myoclonus from cefepime accumulation and for hearing changes.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Cholera vaccine, Dexamethasone-tobramycin, Gentamicin. The full list is on the Cefepime page.
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