Amiloride + Amlodipine-olmesartan-hydrochlorothiazide

MediHelp rates the interaction as major. Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.

MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.