Drug interactions
Amiloride + Amlodipine-olmesartan-hydrochlorothiazide
Severity: Major
Amiloride and Amlodipine-olmesartan-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.
What this interaction means in plain words
Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiloride belongs to Cardiovascular; Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive reduction of renal potassium excretion by angiotensin receptor blockade and ENaC inhibition, partly opposed by thiazide kaliuresis.
What to do
Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide Major
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide Major
Other interactions of Amiloride
- Amiloride + Eplerenone Contraindicated
- Amiloride + Spironolactone Contraindicated
- Amiloride + Triamterene Contraindicated
- Aceclofenac + Amiloride Major
- Acemetacin + Amiloride Major
- Amiloride + Amlodipine-benazepril Major
Frequently asked questions
Can I take Amiloride with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Amiloride and Amlodipine-olmesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olmesartan and amiloride both reduce potassium excretion and can cause hyperkalemia, which hydrochlorothiazide only partly offsets. The risk is highest with renal impairment, diabetes or older age.
How serious is the interaction between Amiloride and Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function soon after starting and periodically thereafter. Stop amiloride and avoid potassium supplements if hyperkalemia develops.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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