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Amiloride + Indomethacin

شدت: شدید

Amiloride and Indomethacin: major interaction.

آخرین به‌روزرسانی

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خلاصه

Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.

معنای این تداخل به زبان ساده

Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiloride belongs to Cardiovascular; Indomethacin belongs to Musculoskeletal.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive potassium retention: amiloride blocks ENaC and indomethacin suppresses prostaglandin-mediated renin and aldosterone and renal potassium excretion.

اقدام لازم

Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amiloride و Indomethacin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amiloride with Indomethacin?

MediHelp rates the interaction as major. Amiloride and Indomethacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indomethacin can blunt renal potassium excretion while amiloride is potassium-sparing, so combined use can cause hyperkalemia. NSAIDs may also reduce the diuretic and antihypertensive effect of amiloride and worsen renal function.

How serious is the interaction between Amiloride and Indomethacin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, monitor serum potassium and creatinine within the first week and periodically after, especially in the elderly, diabetics or those with renal impairment.

What other medicines interact with Indomethacin?

MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.

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