تداخل‌های دارویی
Amiodarone + Digoxin
شدت: شدید
Amiodarone and Digoxin: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Amiodarone increases serum digoxin concentrations, often substantially, and may lead to digoxin toxicity. Additive effects on sinus and AV nodal function raise the risk of bradycardia and heart block. The interaction develops over days to weeks and can persist because of amiodarone's long half-life.
معنای این تداخل به زبان ساده
Amiodarone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Digoxin belongs to Cardiovascular.
چرا رخ می‌دهد
Amiodarone inhibits P-glycoprotein and reduces renal and non-renal digoxin clearance, with additive pharmacodynamic effects on cardiac conduction.
اقدام لازم
Reduce the digoxin dose by roughly one-third to one-half when starting amiodarone, or consider stopping digoxin if no longer necessary. Measure serum digoxin levels and review after one to two weeks, and monitor heart rate and ECG.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amiodarone و Digoxin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Digoxin
تداخلات دیگر Amiodarone
- Amiodarone + Amisulpride منع مصرف
- Amiodarone + Arsenic trioxide منع مصرف
- Amiodarone + Dofetilide منع مصرف
- Amiodarone + Dronedarone منع مصرف
- Amiodarone + Droperidol منع مصرف
- Amiodarone + Eliglustat منع مصرف
پرسش‌های متداول
Can I take Amiodarone with Digoxin?
MediHelp rates the interaction as major. Amiodarone and Digoxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone increases serum digoxin concentrations, often substantially, and may lead to digoxin toxicity. Additive effects on sinus and AV nodal function raise the risk of bradycardia and heart block. The interaction develops over days to weeks and can persist because of amiodarone's long half-life.
How serious is the interaction between Amiodarone and Digoxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the digoxin dose by roughly one-third to one-half when starting amiodarone, or consider stopping digoxin if no longer necessary. Measure serum digoxin levels and review after one to two weeks, and monitor heart rate and ECG.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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