Drug interactions
amiodarone + digoxin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ digoxin exposure → bradyarrhythmias.
Mechanism of action
P-gp inhibition.
Clinical management
Reduce digoxin dose ~50%; monitor levels.
Drug reference
References
Frequently asked questions
Can I take amiodarone with digoxin?
The interaction is rated: Major. ↑ digoxin exposure → bradyarrhythmias.
How serious is the interaction between amiodarone and digoxin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between amiodarone and digoxin managed?
Reduce digoxin dose ~50%; monitor levels.
Why do amiodarone and digoxin interact?
P-gp inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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