تداخل‌های دارویی
Amiodarone + Torsemide
شدت: شدید
Amiodarone and Torsemide: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Torsemide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Amiodarone prolongs repolarization, so electrolyte loss lowers the threshold for arrhythmia. The risk is highest with high diuretic doses, renal dysfunction, bradycardia, structural heart disease, female sex and other QT-prolonging drugs.
معنای این تداخل به زبان ساده
Amiodarone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
چرا رخ می‌دهد
Additive pharmacodynamic effect: loop diuretic-induced potassium and magnesium depletion potentiates the QT-prolonging effect of amiodarone.
اقدام لازم
Check serum potassium and magnesium before starting and periodically during co-therapy, especially after dose changes or intercurrent illness with vomiting or diarrhea. Replete deficits promptly and keep potassium in the high-normal range (about 4.0 mmol/L or above) and magnesium in the normal range.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amiodarone و Torsemide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Amiodarone
- Amiodarone + Amisulpride منع مصرف
- Amiodarone + Arsenic trioxide منع مصرف
- Amiodarone + Dofetilide منع مصرف
- Amiodarone + Dronedarone منع مصرف
- Amiodarone + Droperidol منع مصرف
- Amiodarone + Eliglustat منع مصرف
تداخلات دیگر Torsemide
پرسش‌های متداول
Can I take Amiodarone with Torsemide?
MediHelp rates the interaction as major. Amiodarone and Torsemide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Torsemide can cause hypokalemia and hypomagnesemia, which increase the risk of QT prolongation and torsades de pointes in patients taking amiodarone. Amiodarone prolongs repolarization, so electrolyte loss lowers the threshold for arrhythmia. The risk is highest with high diuretic doses, renal dysfunction, bradycardia, structural heart disease, female sex and other QT-prolonging drugs.
How serious is the interaction between Amiodarone and Torsemide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium before starting and periodically during co-therapy, especially after dose changes or intercurrent illness with vomiting or diarrhea. Replete deficits promptly and keep potassium in the high-normal range (about 4.0 mmol/L or above) and magnesium in the normal range.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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