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تداخل‌های دارویی

Amisulpride + Solifenacin

شدت: شدید

Amisulpride and Solifenacin: major interaction.

آخرین به‌روزرسانی

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خلاصه

Amisulpride prolongs the QT interval in a dose-related way, and solifenacin has been associated with QT prolongation at supratherapeutic doses. Combined use may increase the risk of ventricular arrhythmias, particularly with other risk factors.

معنای این تداخل به زبان ساده

Amisulpride and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amisulpride belongs to Central Nervous System; Solifenacin belongs to Genitourinary.

سطح شواهد: Low

چرا رخ می‌دهد

Additive QT-interval prolongation.

اقدام لازم

Obtain an ECG and check potassium and magnesium before starting, and monitor during co-therapy. Avoid it in patients with congenital long QT, bradycardia, or hypokalemia.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amisulpride و Solifenacin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amisulpride with Solifenacin?

MediHelp rates the interaction as major. Amisulpride and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride prolongs the QT interval in a dose-related way, and solifenacin has been associated with QT prolongation at supratherapeutic doses. Combined use may increase the risk of ventricular arrhythmias, particularly with other risk factors.

How serious is the interaction between Amisulpride and Solifenacin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium before starting, and monitor during co-therapy. Avoid it in patients with congenital long QT, bradycardia, or hypokalemia.

What other medicines interact with Solifenacin?

MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Anagrelide. The full list is on the Solifenacin page.

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