Drug interactions
Amisulpride + Solifenacin
Severity: Major
Amisulpride and Solifenacin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride prolongs the QT interval in a dose-related way, and solifenacin has been associated with QT prolongation at supratherapeutic doses. Combined use may increase the risk of ventricular arrhythmias, particularly with other risk factors.
What this interaction means in plain words
Amisulpride and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT-interval prolongation.
What to do
Obtain an ECG and check potassium and magnesium before starting, and monitor during co-therapy. Avoid it in patients with congenital long QT, bradycardia, or hypokalemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Solifenacin
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Solifenacin?
MediHelp rates the interaction as major. Amisulpride and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amisulpride prolongs the QT interval in a dose-related way, and solifenacin has been associated with QT prolongation at supratherapeutic doses. Combined use may increase the risk of ventricular arrhythmias, particularly with other risk factors.
How serious is the interaction between Amisulpride and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and check potassium and magnesium before starting, and monitor during co-therapy. Avoid it in patients with congenital long QT, bradycardia, or hypokalemia.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Anagrelide. The full list is on the Solifenacin page.
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