تداخل‌های دارویی
Amitriptyline + Bedaquiline
شدت: شدید
Amitriptyline and Bedaquiline: major interaction.
آخرین به‌روزرسانی
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خلاصه
Both drugs can prolong the QT interval, so using them together raises the chance of clinically significant QTc prolongation and torsades de pointes. The risk is greater with electrolyte disturbances, cardiac disease or other QT-prolonging drugs.
معنای این تداخل به زبان ساده
Amitriptyline and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amitriptyline belongs to Central Nervous System; Bedaquiline belongs to Anti Bacterial.
چرا رخ می‌دهد
Additive pharmacodynamic prolongation of cardiac repolarization through blockade of cardiac potassium channels.
اقدام لازم
Obtain a baseline ECG and repeat it periodically during co-treatment, and correct potassium, magnesium and calcium abnormalities. Stop or replace amitriptyline if QTc becomes markedly prolonged.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Bedaquiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Amitriptyline
- Amitriptyline + Isocarboxazid منع مصرف
- Amitriptyline + Methylene blue منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amitriptyline + Pimozide منع مصرف
- Amitriptyline + Procarbazine منع مصرف
- Amitriptyline + Safinamide منع مصرف
تداخلات دیگر Bedaquiline
پرسش‌های متداول
Can I take Amitriptyline with Bedaquiline?
MediHelp rates the interaction as major. Amitriptyline and Bedaquiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so using them together raises the chance of clinically significant QTc prolongation and torsades de pointes. The risk is greater with electrolyte disturbances, cardiac disease or other QT-prolonging drugs.
How serious is the interaction between Amitriptyline and Bedaquiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it periodically during co-treatment, and correct potassium, magnesium and calcium abnormalities. Stop or replace amitriptyline if QTc becomes markedly prolonged.
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.
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