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Amitriptyline + Thioridazine

شدت: منع مصرف

Amitriptyline and Thioridazine: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Thioridazine is a strong QT-prolonging antipsychotic, and amitriptyline adds further QT and conduction effects. The combination markedly increases the risk of torsades de pointes and sudden cardiac death.

معنای این تداخل به زبان ساده

Amitriptyline and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amitriptyline belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive QT prolongation, with thioridazine also inhibiting CYP2D6 and raising amitriptyline levels.

اقدام لازم

Do not combine these drugs; select an alternative antipsychotic or antidepressant with less cardiac liability.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Thioridazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amitriptyline with Thioridazine?

MediHelp rates the interaction as contraindicated. Amitriptyline and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine is a strong QT-prolonging antipsychotic, and amitriptyline adds further QT and conduction effects. The combination markedly increases the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Amitriptyline and Thioridazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine these drugs; select an alternative antipsychotic or antidepressant with less cardiac liability.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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