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Amitriptyline + Vandetanib

شدت: منع مصرف

Amitriptyline and Vandetanib: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Vandetanib markedly prolongs the QT interval and has been associated with torsades de pointes and sudden death. Adding amitriptyline, which also prolongs QT, increases that risk further.

معنای این تداخل به زبان ساده

Amitriptyline and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Amitriptyline belongs to Central Nervous System; Vandetanib belongs to Oncology.

سطح شواهد: High

چرا رخ می‌دهد

Additive QT prolongation through cardiac potassium channel effects.

اقدام لازم

Avoid the combination and choose a non-QT-prolonging antidepressant. If a QT-prolonging drug cannot be avoided, use intensive ECG and electrolyte monitoring.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amitriptyline و Vandetanib، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amitriptyline with Vandetanib?

MediHelp rates the interaction as contraindicated. Amitriptyline and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib markedly prolongs the QT interval and has been associated with torsades de pointes and sudden death. Adding amitriptyline, which also prolongs QT, increases that risk further.

How serious is the interaction between Amitriptyline and Vandetanib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. If a QT-prolonging drug cannot be avoided, use intensive ECG and electrolyte monitoring.

What other medicines interact with Amitriptyline?

MediHelp also lists interactions of Amitriptyline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Amitriptyline page.

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