تداخل‌های دارویی
Amlodipine-atorvastatin + Apalutamide
شدت: شدید
Amlodipine-atorvastatin and Apalutamide: major interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Apalutamide is a strong CYP3A4 inducer and can substantially lower exposure to amlodipine and atorvastatin, both CYP3A4 substrates. This may lead to loss of blood pressure control and reduced lipid-lowering efficacy. The induction effect develops over days to weeks and persists after apalutamide is stopped.
معنای این تداخل به زبان ساده
Amlodipine-atorvastatin and Apalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Apalutamide belongs to Endocrine.
چرا رخ می‌دهد
Induction of CYP3A4 (and related transporters) by apalutamide increases the metabolism of amlodipine and atorvastatin.
اقدام لازم
Monitor blood pressure and LDL cholesterol, and increase doses of amlodipine or atorvastatin if needed, or switch to a less CYP3A4-dependent agent. Reassess doses after apalutamide is discontinued.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amlodipine-atorvastatin و Apalutamide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Amlodipine-atorvastatin
تداخلات دیگر Apalutamide
- Apalutamide + Cabotegravir منع مصرف
- Apalutamide + Cobicistat منع مصرف
- Apalutamide + Doravirine منع مصرف
- Apalutamide + Elbasvir / grazoprevir منع مصرف
- Apalutamide + Ensitrelvir منع مصرف
- Apalutamide + Fostemsavir منع مصرف
پرسش‌های متداول
Can I take Amlodipine-atorvastatin with Apalutamide?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Apalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and can substantially lower exposure to amlodipine and atorvastatin, both CYP3A4 substrates. This may lead to loss of blood pressure control and reduced lipid-lowering efficacy. The induction effect develops over days to weeks and persists after apalutamide is stopped.
How serious is the interaction between Amlodipine-atorvastatin and Apalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and LDL cholesterol, and increase doses of amlodipine or atorvastatin if needed, or switch to a less CYP3A4-dependent agent. Reassess doses after apalutamide is discontinued.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Atazanavir, Clarithromycin. The full list is on the Amlodipine-atorvastatin page.
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