Drug interactions
Amlodipine-atorvastatin + Apalutamide
Severity: Major
Amlodipine-atorvastatin and Apalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can substantially lower exposure to amlodipine and atorvastatin, both CYP3A4 substrates. This may lead to loss of blood pressure control and reduced lipid-lowering efficacy. The induction effect develops over days to weeks and persists after apalutamide is stopped.
What this interaction means in plain words
Amlodipine-atorvastatin and Apalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-atorvastatin belongs to Cardiovascular; Apalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 (and related transporters) by apalutamide increases the metabolism of amlodipine and atorvastatin.
What to do
Monitor blood pressure and LDL cholesterol, and increase doses of amlodipine or atorvastatin if needed, or switch to a less CYP3A4-dependent agent. Reassess doses after apalutamide is discontinued.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amlodipine-atorvastatin and Apalutamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amlodipine-atorvastatin
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Apalutamide?
MediHelp rates the interaction as major. Amlodipine-atorvastatin and Apalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 inducer and can substantially lower exposure to amlodipine and atorvastatin, both CYP3A4 substrates. This may lead to loss of blood pressure control and reduced lipid-lowering efficacy. The induction effect develops over days to weeks and persists after apalutamide is stopped.
How serious is the interaction between Amlodipine-atorvastatin and Apalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and LDL cholesterol, and increase doses of amlodipine or atorvastatin if needed, or switch to a less CYP3A4-dependent agent. Reassess doses after apalutamide is discontinued.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Atazanavir, Clarithromycin. The full list is on the Amlodipine-atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
