Amlodipine-hydrochlorothiazide-valsartan + Benazepril

MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding an ACE inhibitor to a regimen already containing the angiotensin receptor blocker valsartan produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful cardiovascular benefit in most patients.

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single renin-angiotensin agent. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.