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تداخل‌های دارویی

Amlodipine-hydrochlorothiazide-valsartan + Diclofenac

شدت: شدید

Amlodipine-hydrochlorothiazide-valsartan and Diclofenac: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Diclofenac can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide. The combination of an NSAID, ARB and diuretic is associated with acute kidney injury, particularly in elderly or volume-depleted patients, and may also cause hyperkalemia.

معنای این تداخل به زبان ساده

Amlodipine-hydrochlorothiazide-valsartan and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Diclofenac belongs to Musculoskeletal.

سطح شواهد: High

چرا رخ می‌دهد

NSAID inhibition of renal prostaglandins reduces afferent arteriolar dilation and promotes salt retention, while ARB and diuretic reduce glomerular perfusion pressure and volume.

اقدام لازم

Avoid regular NSAID use where possible and prefer paracetamol or topical options. If needed, use the lowest dose briefly, maintain hydration and monitor blood pressure, creatinine and potassium.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amlodipine-hydrochlorothiazide-valsartan و Diclofenac، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
ساخت حساب رایگان ورود

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amlodipine-hydrochlorothiazide-valsartan with Diclofenac?

MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac can reduce the antihypertensive efficacy of valsartan and hydrochlorothiazide. The combination of an NSAID, ARB and diuretic is associated with acute kidney injury, particularly in elderly or volume-depleted patients, and may also cause hyperkalemia.

How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Diclofenac?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and prefer paracetamol or topical options. If needed, use the lowest dose briefly, maintain hydration and monitor blood pressure, creatinine and potassium.

What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?

MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.

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