تداخل‌های دارویی
Amoxapine + Donepezil
شدت: شدید
Amoxapine and Donepezil: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Donepezil has a known risk of QT prolongation and torsades de pointes, and amoxapine, a tricyclic-related antidepressant, can also prolong the QT interval. Combined use may raise arrhythmia risk, especially with electrolyte disturbance or cardiac disease. Amoxapine's anticholinergic activity may also oppose donepezil's cholinergic benefit.
معنای این تداخل به زبان ساده
Amoxapine and Donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive QT prolongation, plus pharmacodynamic opposition of cholinesterase inhibition by antimuscarinic effects.
اقدام لازم
Avoid the combination where possible; if used, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc. Consider an antidepressant with less QT and anticholinergic liability.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amoxapine و Donepezil، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Donepezil
- Donepezil + Dronedarone منع مصرف
- Donepezil + Pimozide منع مصرف
- Donepezil + Thioridazine منع مصرف
- Donepezil + Vandetanib منع مصرف
- Amiodarone + Donepezil شدید
- Amisulpride + Donepezil شدید
پرسش‌های متداول
Can I take Amoxapine with Donepezil?
MediHelp rates the interaction as major. Amoxapine and Donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Donepezil has a known risk of QT prolongation and torsades de pointes, and amoxapine, a tricyclic-related antidepressant, can also prolong the QT interval. Combined use may raise arrhythmia risk, especially with electrolyte disturbance or cardiac disease. Amoxapine's anticholinergic activity may also oppose donepezil's cholinergic benefit.
How serious is the interaction between Amoxapine and Donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc. Consider an antidepressant with less QT and anticholinergic liability.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
