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تداخل‌های دارویی

Amphotericin b deoxycholate + Cidofovir

شدت: منع مصرف

Amphotericin b deoxycholate and Cidofovir: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both drugs injure the kidney, and their combined use can cause acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its labeling prohibits concomitant nephrotoxic agents.

معنای این تداخل به زبان ساده

Amphotericin b deoxycholate and Cidofovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

Additive nephrotoxicity: cidofovir causes proximal tubular injury and amphotericin B causes tubular toxicity and renal vasoconstriction.

اقدام لازم

Do not use together; stop amphotericin at least 7 days before cidofovir where possible and choose an alternative agent. Monitor serum creatinine and urine protein before each cidofovir dose.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amphotericin b deoxycholate و Cidofovir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amphotericin b deoxycholate with Cidofovir?

MediHelp rates the interaction as contraindicated. Amphotericin b deoxycholate and Cidofovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs injure the kidney, and their combined use can cause acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its labeling prohibits concomitant nephrotoxic agents.

How serious is the interaction between Amphotericin b deoxycholate and Cidofovir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop amphotericin at least 7 days before cidofovir where possible and choose an alternative agent. Monitor serum creatinine and urine protein before each cidofovir dose.

What other medicines interact with Cidofovir?

MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b, Bacitracin. The full list is on the Cidofovir page.

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