Drug interactions
Amphotericin b deoxycholate + Cidofovir
Severity: Contraindicated
Amphotericin b deoxycholate and Cidofovir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs injure the kidney, and their combined use can cause acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its labeling prohibits concomitant nephrotoxic agents.
What this interaction means in plain words
Amphotericin b deoxycholate and Cidofovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive nephrotoxicity: cidofovir causes proximal tubular injury and amphotericin B causes tubular toxicity and renal vasoconstriction.
What to do
Do not use together; stop amphotericin at least 7 days before cidofovir where possible and choose an alternative agent. Monitor serum creatinine and urine protein before each cidofovir dose.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Amphotericin b deoxycholate and Cidofovir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
- Cidofovir + Cisplatin Contraindicated
Frequently asked questions
Can I take Amphotericin b deoxycholate with Cidofovir?
MediHelp rates the interaction as contraindicated. Amphotericin b deoxycholate and Cidofovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs injure the kidney, and their combined use can cause acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its labeling prohibits concomitant nephrotoxic agents.
How serious is the interaction between Amphotericin b deoxycholate and Cidofovir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop amphotericin at least 7 days before cidofovir where possible and choose an alternative agent. Monitor serum creatinine and urine protein before each cidofovir dose.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b, Bacitracin. The full list is on the Cidofovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
