تداخلهای دارویی
Amphotericin b deoxycholate + Cisplatin
شدت: شدید
Amphotericin b deoxycholate and Cisplatin: major interaction.
آخرین بهروزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصهای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمیشود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both drugs are nephrotoxic, and cisplatin is also ototoxic. Combined use raises the risk of acute kidney injury, electrolyte wasting such as hypomagnesemia and hypokalemia, and further cisplatin toxicity from reduced clearance.
معنای این تداخل به زبان ساده
Amphotericin b deoxycholate and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ میدهد
Additive renal tubular toxicity and vasoconstriction, with impaired renal elimination of cisplatin.
اقدام لازم
Avoid if possible, using a lipid amphotericin formulation or alternative antifungal. If unavoidable, hydrate, and monitor creatinine, magnesium and potassium frequently.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Amphotericin b deoxycholate و Cisplatin، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cisplatin
پرسشهای متداول
Can I take Amphotericin b deoxycholate with Cisplatin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and cisplatin is also ototoxic. Combined use raises the risk of acute kidney injury, electrolyte wasting such as hypomagnesemia and hypokalemia, and further cisplatin toxicity from reduced clearance.
How serious is the interaction between Amphotericin b deoxycholate and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, using a lipid amphotericin formulation or alternative antifungal. If unavoidable, hydrate, and monitor creatinine, magnesium and potassium frequently.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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