Drug interactions
Amphotericin b deoxycholate + Cisplatin
Severity: Major
Amphotericin b deoxycholate and Cisplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and cisplatin is also ototoxic. Combined use raises the risk of acute kidney injury, electrolyte wasting such as hypomagnesemia and hypokalemia, and further cisplatin toxicity from reduced clearance.
What this interaction means in plain words
Amphotericin b deoxycholate and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive renal tubular toxicity and vasoconstriction, with impaired renal elimination of cisplatin.
What to do
Avoid if possible, using a lipid amphotericin formulation or alternative antifungal. If unavoidable, hydrate, and monitor creatinine, magnesium and potassium frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b + Cisplatin Major
- Bacitracin + Cisplatin Major
Frequently asked questions
Can I take Amphotericin b deoxycholate with Cisplatin?
MediHelp rates the interaction as major. Amphotericin b deoxycholate and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and cisplatin is also ototoxic. Combined use raises the risk of acute kidney injury, electrolyte wasting such as hypomagnesemia and hypokalemia, and further cisplatin toxicity from reduced clearance.
How serious is the interaction between Amphotericin b deoxycholate and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, using a lipid amphotericin formulation or alternative antifungal. If unavoidable, hydrate, and monitor creatinine, magnesium and potassium frequently.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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