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Amphotericin b deoxycholate + Colistin

شدت: شدید

Amphotericin b deoxycholate and Colistin: major interaction.

آخرین به‌روزرسانی

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خلاصه

Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.

معنای این تداخل به زبان ساده

Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive direct tubular toxicity and renal vasoconstriction.

اقدام لازم

Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amphotericin b deoxycholate و Colistin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amphotericin b deoxycholate with Colistin?

MediHelp rates the interaction as major. Amphotericin b deoxycholate and Colistin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and using them together increases the chance of acute kidney injury. Colistin also carries neurotoxic effects, and renal impairment raises its exposure further.

How serious is the interaction between Amphotericin b deoxycholate and Colistin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if alternatives exist; otherwise monitor serum creatinine and electrolytes frequently, keep patients well hydrated and adjust colistin dose to renal function.

What other medicines interact with Colistin?

MediHelp also lists interactions of Colistin with, for example, Polymyxin b, Amikacin, Amphotericin b. The full list is on the Colistin page.

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