Amphotericin b liposomal + Tenofovir disoproxil

MediHelp rates the interaction as moderate. Amphotericin b liposomal and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can injure the kidney, and giving them together may add to the risk of renal impairment. Reduced kidney function can in turn raise tenofovir exposure and worsen tubular toxicity. The liposomal formulation is generally less nephrotoxic than conventional amphotericin B.

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, estimated creatinine clearance, phosphate and electrolytes regularly during combined use. Adjust the tenofovir interval for renal function or choose an alternative if renal function falls.

MediHelp also lists interactions of Amphotericin b liposomal with, for example, Amlodipine-benazepril, Benazepril, Captopril-hydrochlorothiazide. The full list is on the Amphotericin b liposomal page.