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Amyl nitrite + Vardenafil

شدت: منع مصرف

Amyl nitrite and Vardenafil: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Vardenafil greatly enhances the vasodilator effect of nitrates such as amyl nitrite. This can cause severe, potentially fatal hypotension.

معنای این تداخل به زبان ساده

Amyl nitrite and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

Nitrates increase cGMP through nitric oxide and vardenafil inhibits its degradation by PDE5, causing excessive vasodilation.

اقدام لازم

Do not co-administer, including recreational nitrite inhalants. Keep a safe interval, at least 24 hours, before any nitrate is given after vardenafil.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amyl nitrite و Vardenafil، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amyl nitrite with Vardenafil?

MediHelp rates the interaction as contraindicated. Amyl nitrite and Vardenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vardenafil greatly enhances the vasodilator effect of nitrates such as amyl nitrite. This can cause severe, potentially fatal hypotension.

How serious is the interaction between Amyl nitrite and Vardenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, including recreational nitrite inhalants. Keep a safe interval, at least 24 hours, before any nitrate is given after vardenafil.

What other medicines interact with Vardenafil?

MediHelp also lists interactions of Vardenafil with, for example, Glyceryl trinitrate pr, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Vardenafil page.

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