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تداخل‌های دارویی

Apixaban + Celecoxib

شدت: شدید

Apixaban and Celecoxib: major interaction.

آخرین به‌روزرسانی

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خلاصه

Celecoxib has less antiplatelet effect than nonselective NSAIDs but can still cause gastrointestinal mucosal injury, and apixaban adds anticoagulation. The combination increases the risk of clinically significant bleeding.

معنای این تداخل به زبان ساده

Apixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Apixaban belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive bleeding risk from NSAID mucosal injury and factor Xa inhibition.

اقدام لازم

Avoid if possible and use paracetamol for pain. If celecoxib is required, give the lowest dose for the shortest time with gastroprotection and monitor for bleeding.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Apixaban و Celecoxib، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Apixaban with Celecoxib?

MediHelp rates the interaction as major. Apixaban and Celecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Celecoxib has less antiplatelet effect than nonselective NSAIDs but can still cause gastrointestinal mucosal injury, and apixaban adds anticoagulation. The combination increases the risk of clinically significant bleeding.

How serious is the interaction between Apixaban and Celecoxib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use paracetamol for pain. If celecoxib is required, give the lowest dose for the shortest time with gastroprotection and monitor for bleeding.

What other medicines interact with Celecoxib?

MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.

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