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تداخل‌های دارویی

Apixaban + Edoxaban

شدت: منع مصرف

Apixaban and Edoxaban: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.

معنای این تداخل به زبان ساده

Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apixaban belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.

سطح شواهد: Moderate

چرا رخ می‌دهد

Duplicate pharmacodynamic effect through factor Xa inhibition.

اقدام لازم

Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Apixaban و Edoxaban، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Apixaban with Edoxaban?

MediHelp rates the interaction as contraindicated. Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.

How serious is the interaction between Apixaban and Edoxaban?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.

What other medicines interact with Apixaban?

MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Ketorolac. The full list is on the Apixaban page.

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