Drug interactions
Apixaban + Edoxaban
Severity: Contraindicated
Apixaban and Edoxaban: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
What this interaction means in plain words
Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Apixaban belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Why it happens
Duplicate pharmacodynamic effect through factor Xa inhibition.
What to do
Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
- Acalabrutinib + Apixaban Major
Other interactions of Edoxaban
- Defibrotide + Edoxaban Contraindicated
- Edoxaban + Ketorolac Contraindicated
- Abciximab + Edoxaban Major
- Acetylsalicylic acid + Edoxaban Major
- Argatroban + Edoxaban Major
- Aspirin rectal + Edoxaban Major
Frequently asked questions
Can I take Apixaban with Edoxaban?
MediHelp rates the interaction as contraindicated. Apixaban and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are direct factor Xa inhibitors, so using them together duplicates anticoagulation and markedly increases bleeding risk with no added benefit. Overlap is acceptable only briefly when switching between agents.
How serious is the interaction between Apixaban and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-prescribe. When switching, stop one agent and start the other at the time the next dose of the first would be due.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Ketorolac. The full list is on the Apixaban page.
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