Aspirin / citric acid / sodium bicarbonate + Vitamin c

MediHelp rates the interaction as minor. Aspirin / citric acid / sodium bicarbonate and Vitamin c have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aspirin may modestly reduce ascorbic acid levels, while vitamin C may slightly raise salicylate retention. The alkalinizing bicarbonate component tends to offset urinary acidification, so clinical effects are negligible at usual doses.

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed at usual doses. Avoid very high-dose vitamin C with chronic high-dose salicylate therapy.

MediHelp also lists interactions of Vitamin c with, for example, Deferoxamine, Aluminum hydroxide, Dextroamphetamine transdermal. The full list is on the Vitamin c page.