تداخل‌های دارویی
Atazanavir + Sildenafil
شدت: منع مصرف
Atazanavir and Sildenafil: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Atazanavir inhibits CYP3A4 and can markedly raise sildenafil exposure, increasing the risk of hypotension, syncope, visual disturbances and priapism. With the higher, chronic dosing used for pulmonary arterial hypertension the risk is unacceptable.
معنای این تداخل به زبان ساده
Atazanavir and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Atazanavir belongs to Anti Virals; Sildenafil belongs to Genitourinary.
چرا رخ می‌دهد
Atazanavir inhibits CYP3A4-mediated first-pass and hepatic metabolism of sildenafil, raising its plasma concentrations.
اقدام لازم
Do not combine atazanavir with sildenafil for pulmonary arterial hypertension. For erectile dysfunction, use a reduced sildenafil dose (for example 25 mg no more often than every 48 hours) and counsel on hypotension and priapism.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Atazanavir و Sildenafil، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Sildenafil
تداخلات دیگر Atazanavir
- Alfuzosin + Atazanavir منع مصرف
- Atazanavir + Avanafil منع مصرف
- Atazanavir + Dronedarone منع مصرف
- Atazanavir + Eletriptan منع مصرف
- Atazanavir + Eplerenone منع مصرف
- Atazanavir + Ergotamine منع مصرف
پرسش‌های متداول
Can I take Atazanavir with Sildenafil?
MediHelp rates the interaction as contraindicated. Atazanavir and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Atazanavir inhibits CYP3A4 and can markedly raise sildenafil exposure, increasing the risk of hypotension, syncope, visual disturbances and priapism. With the higher, chronic dosing used for pulmonary arterial hypertension the risk is unacceptable.
How serious is the interaction between Atazanavir and Sildenafil?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine atazanavir with sildenafil for pulmonary arterial hypertension. For erectile dysfunction, use a reduced sildenafil dose (for example 25 mg no more often than every 48 hours) and counsel on hypotension and priapism.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Cobicistat, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Sildenafil page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
