تداخل‌های دارویی
Atorvastatin + Cyclosporine
شدت: شدید
Atorvastatin and Cyclosporine: major interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cyclosporine markedly increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin labeling advises avoiding the combination. Transplant recipients, older patients and those with renal impairment are at particular risk.
معنای این تداخل به زبان ساده
Atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Cyclosporine inhibits OATP1B1 hepatic uptake and also inhibits CYP3A4 and P-gp, reducing atorvastatin clearance and increasing systemic levels.
اقدام لازم
Avoid concomitant use per atorvastatin labeling; consider fluvastatin, pravastatin or rosuvastatin at limited doses as recommended in their labels. If a statin is required, use the lowest effective dose and monitor for muscle symptoms, with CK measurement if they appear.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Atorvastatin و Cyclosporine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Atorvastatin
پرسش‌های متداول
Can I take Atorvastatin with Cyclosporine?
MediHelp rates the interaction as major. Atorvastatin and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine markedly increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin labeling advises avoiding the combination. Transplant recipients, older patients and those with renal impairment are at particular risk.
How serious is the interaction between Atorvastatin and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use per atorvastatin labeling; consider fluvastatin, pravastatin or rosuvastatin at limited doses as recommended in their labels. If a statin is required, use the lowest effective dose and monitor for muscle symptoms, with CK measurement if they appear.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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