تداخل‌های دارویی
Axicabtagene ciloleucel + Hydroxyurea
شدت: شدید
Axicabtagene ciloleucel and Hydroxyurea: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Hydroxyurea is myelosuppressive and may affect lymphocyte collection and CAR-T expansion. It may also add to infection risk after infusion.
معنای این تداخل به زبان ساده
Axicabtagene ciloleucel and Hydroxyurea can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Axicabtagene ciloleucel belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
چرا رخ می‌دهد
Cytotoxic and myelosuppressive effects may impair T-cell collection and expansion and add immunosuppression.
اقدام لازم
Stop hydroxyurea before leukapheresis and lymphodepletion, following the product labeling and treating team's guidance. Monitor for infection and cytopenias.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Axicabtagene ciloleucel و Hydroxyurea، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Hydroxyurea
تداخلات دیگر Axicabtagene ciloleucel
پرسش‌های متداول
Can I take Axicabtagene ciloleucel with Hydroxyurea?
MediHelp rates the interaction as major. Axicabtagene ciloleucel and Hydroxyurea can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Hydroxyurea is myelosuppressive and may affect lymphocyte collection and CAR-T expansion. It may also add to infection risk after infusion.
How serious is the interaction between Axicabtagene ciloleucel and Hydroxyurea?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop hydroxyurea before leukapheresis and lymphodepletion, following the product labeling and treating team's guidance. Monitor for infection and cytopenias.
What other medicines interact with Hydroxyurea?
MediHelp also lists interactions of Hydroxyurea with, for example, Didanosine, Adenovirus types 4 and 7 live, Bcg intravesical live. The full list is on the Hydroxyurea page.
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مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
