تداخل‌های دارویی
Azacitidine + Siponimod
شدت: شدید
Azacitidine and Siponimod: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Azacitidine is a hypomethylating agent that commonly causes neutropenia and thrombocytopenia, which adds to siponimod's lymphocyte reduction. The combined effect can raise the risk of serious infection.
معنای این تداخل به زبان ساده
Azacitidine and Siponimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azacitidine belongs to Oncology; Siponimod belongs to Central Nervous System.
چرا رخ می‌دهد
Additive immunosuppression from myelosuppression by azacitidine and S1P receptor mediated lymphocyte sequestration by siponimod.
اقدام لازم
Avoid combining if possible; if used, monitor CBC with differential regularly and watch closely for infection. Consider suspending siponimod during myelosuppressive cycles.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Azacitidine و Siponimod، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Siponimod
- Cladribine + Siponimod منع مصرف
- Fingolimod + Siponimod منع مصرف
- Fluconazole + Siponimod منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Siponimod منع مصرف
- Ponesimod + Siponimod منع مصرف
- Siponimod + Thioridazine منع مصرف
تداخلات دیگر Azacitidine
پرسش‌های متداول
Can I take Azacitidine with Siponimod?
MediHelp rates the interaction as major. Azacitidine and Siponimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azacitidine is a hypomethylating agent that commonly causes neutropenia and thrombocytopenia, which adds to siponimod's lymphocyte reduction. The combined effect can raise the risk of serious infection.
How serious is the interaction between Azacitidine and Siponimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if possible; if used, monitor CBC with differential regularly and watch closely for infection. Consider suspending siponimod during myelosuppressive cycles.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
