تداخل‌های دارویی
Siponimod + Thioridazine
شدت: منع مصرف
Siponimod and Thioridazine: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.
معنای این تداخل به زبان ساده
Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Siponimod belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
چرا رخ می‌دهد
Siponimod-induced heart rate slowing combined with thioridazine-induced QT prolongation increases torsades risk.
اقدام لازم
Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Siponimod و Thioridazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Thioridazine
- Abiraterone + Thioridazine منع مصرف
- Adagrasib + Thioridazine منع مصرف
- Amiodarone + Thioridazine منع مصرف
- Amisulpride + Thioridazine منع مصرف
- Amitriptyline + Thioridazine منع مصرف
- Amoxapine + Thioridazine منع مصرف
تداخلات دیگر Siponimod
- Cladribine + Siponimod منع مصرف
- Fingolimod + Siponimod منع مصرف
- Fluconazole + Siponimod منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Siponimod منع مصرف
- Ponesimod + Siponimod منع مصرف
- Adenovirus types 4 and 7 live + Siponimod شدید
پرسش‌های متداول
Can I take Siponimod with Thioridazine?
MediHelp rates the interaction as contraindicated. Siponimod and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Siponimod can cause bradycardia and atrioventricular conduction delay at initiation, and thioridazine prolongs QTc. Bradycardia increases vulnerability to torsades de pointes. Siponimod labeling advises against use with QT-prolonging drugs. Thioridazine, a CYP2D6 substrate and inhibitor, is not expected to alter siponimod CYP2C9 metabolism meaningfully.
How serious is the interaction between Siponimod and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a different antipsychotic. If it cannot be avoided, obtain cardiology advice and ECG monitoring at initiation.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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