تداخل‌های دارویی
Baricitinib + Natalizumab
شدت: شدید
Baricitinib and Natalizumab: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Natalizumab impairs lymphocyte entry into tissues including the CNS and is linked to progressive multifocal leukoencephalopathy. Baricitinib is a JAK inhibitor that adds broad immunosuppression, increasing the risk of serious and opportunistic infections.
معنای این تداخل به زبان ساده
Baricitinib and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Natalizumab belongs to Gastrointestinal Tract.
چرا رخ می‌دهد
Additive immunosuppression through integrin blockade and JAK inhibition.
اقدام لازم
Avoid the combination. Choose one agent, and monitor for infection and new neurological symptoms if overlap cannot be avoided.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Baricitinib و Natalizumab، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Natalizumab
تداخلات دیگر Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib منع مصرف
- Baricitinib + Bcg vaccine live منع مصرف
- Baricitinib + Tofacitinib منع مصرف
- Baricitinib + Upadacitinib منع مصرف
- Abatacept + Baricitinib شدید
- Adalimumab + Baricitinib شدید
پرسش‌های متداول
Can I take Baricitinib with Natalizumab?
MediHelp rates the interaction as major. Baricitinib and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Natalizumab impairs lymphocyte entry into tissues including the CNS and is linked to progressive multifocal leukoencephalopathy. Baricitinib is a JAK inhibitor that adds broad immunosuppression, increasing the risk of serious and opportunistic infections.
How serious is the interaction between Baricitinib and Natalizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose one agent, and monitor for infection and new neurological symptoms if overlap cannot be avoided.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Vedolizumab, Axicabtagene ciloleucel, Belatacept. The full list is on the Natalizumab page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
