Drug interactions
Baricitinib + Natalizumab
Severity: Major
Baricitinib and Natalizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Natalizumab impairs lymphocyte entry into tissues including the CNS and is linked to progressive multifocal leukoencephalopathy. Baricitinib is a JAK inhibitor that adds broad immunosuppression, increasing the risk of serious and opportunistic infections.
What this interaction means in plain words
Baricitinib and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baricitinib belongs to Musculoskeletal; Natalizumab belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression through integrin blockade and JAK inhibition.
What to do
Avoid the combination. Choose one agent, and monitor for infection and new neurological symptoms if overlap cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Natalizumab
- Natalizumab + Vedolizumab Contraindicated
- Axicabtagene ciloleucel + Natalizumab Major
- Belatacept + Natalizumab Major
- Brexucabtagene autoleucel + Natalizumab Major
- Cabazitaxel + Natalizumab Major
- Certolizumab pegol + Natalizumab Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Natalizumab?
MediHelp rates the interaction as major. Baricitinib and Natalizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Natalizumab impairs lymphocyte entry into tissues including the CNS and is linked to progressive multifocal leukoencephalopathy. Baricitinib is a JAK inhibitor that adds broad immunosuppression, increasing the risk of serious and opportunistic infections.
How serious is the interaction between Baricitinib and Natalizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Choose one agent, and monitor for infection and new neurological symptoms if overlap cannot be avoided.
What other medicines interact with Natalizumab?
MediHelp also lists interactions of Natalizumab with, for example, Vedolizumab, Axicabtagene ciloleucel, Belatacept. The full list is on the Natalizumab page.
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