تداخل‌های دارویی
Benzathine penicillin g + Vadadustat
شدت: متوسط
Benzathine penicillin g and Vadadustat: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
معنای این تداخل به زبان ساده
Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benzathine penicillin g belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
چرا رخ می‌دهد
Penicillin G competes for OAT1/OAT3-mediated renal transport, which may reduce vadadustat clearance.
اقدام لازم
Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Benzathine penicillin g و Vadadustat، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine متوسط
- Benzathine penicillin g + Microbiota متوسط
- Benzathine penicillin g + Omadacycline متوسط
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid متوسط
- Amifampridine + Benzathine penicillin g جزئی
- Baricitinib + Benzathine penicillin g جزئی
تداخلات دیگر Vadadustat
پرسش‌های متداول
Can I take Benzathine penicillin g with Vadadustat?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
How serious is the interaction between Benzathine penicillin g and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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