Drug interactions
Benzathine penicillin g + Vadadustat
Severity: Moderate
Benzathine penicillin g and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
What this interaction means in plain words
Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benzathine penicillin g belongs to Anti Bacterial; Vadadustat belongs to Endocrine.
Why it happens
Penicillin G competes for OAT1/OAT3-mediated renal transport, which may reduce vadadustat clearance.
What to do
Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Amifampridine + Benzathine penicillin g Minor
- Baricitinib + Benzathine penicillin g Minor
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
- Cladribine + Vadadustat Moderate
Frequently asked questions
Can I take Benzathine penicillin g with Vadadustat?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Penicillin G can inhibit the renal transporters OAT1 and OAT3, which are involved in vadadustat elimination. Vadadustat exposure may therefore increase, raising the risk of an excessive hemoglobin rise and adverse effects. The clinical significance is likely small with benzathine penicillin because of its low and prolonged serum levels.
How serious is the interaction between Benzathine penicillin g and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin response and for vadadustat adverse reactions during concurrent use. Reduce the vadadustat dose if hemoglobin rises too rapidly.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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