تداخل‌های دارویی
Bosentan + Cyclosporine
شدت: منع مصرف
Bosentan and Cyclosporine: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cyclosporine markedly increases bosentan plasma concentrations, while bosentan lowers cyclosporine levels. The rise in bosentan raises the risk of hepatotoxicity, and reduced cyclosporine can compromise immunosuppression and risk graft rejection. Labeling advises against concomitant use.
معنای این تداخل به زبان ساده
Bosentan and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Cyclosporine inhibits OATP-mediated hepatic uptake and CYP3A4 metabolism of bosentan, while bosentan induces CYP3A4, accelerating cyclosporine metabolism.
اقدام لازم
Do not co-administer; select an alternative pulmonary hypertension therapy, such as a PDE5 inhibitor, if cyclosporine is required. If bosentan is already in use, discuss alternatives with the transplant and pulmonary hypertension teams before starting cyclosporine.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Bosentan و Cyclosporine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Bosentan
- Bosentan + Cyclosporin منع مصرف
- Bosentan + Glyburide منع مصرف
- Bosentan + Glyburide-metformin منع مصرف
- Bosentan + Lonafarnib منع مصرف
- Bosentan + Sparsentan منع مصرف
- Artemether / lumefantrine + Bosentan شدید
پرسش‌های متداول
Can I take Bosentan with Cyclosporine?
MediHelp rates the interaction as contraindicated. Bosentan and Cyclosporine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine markedly increases bosentan plasma concentrations, while bosentan lowers cyclosporine levels. The rise in bosentan raises the risk of hepatotoxicity, and reduced cyclosporine can compromise immunosuppression and risk graft rejection. Labeling advises against concomitant use.
How serious is the interaction between Bosentan and Cyclosporine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; select an alternative pulmonary hypertension therapy, such as a PDE5 inhibitor, if cyclosporine is required. If bosentan is already in use, discuss alternatives with the transplant and pulmonary hypertension teams before starting cyclosporine.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Glyburide, Glyburide-metformin. The full list is on the Bosentan page.
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