تداخل‌های دارویی
Brentuximab vedotin + Siponimod
شدت: شدید
Brentuximab vedotin and Siponimod: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Brentuximab vedotin can cause neutropenia and serious infections, and it carries a risk of progressive multifocal leukoencephalopathy. Siponimod also carries infection and PML risk, so the combination may increase these concerns.
معنای این تداخل به زبان ساده
Brentuximab vedotin and Siponimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab vedotin belongs to Oncology; Siponimod belongs to Central Nervous System.
چرا رخ می‌دهد
Additive immunosuppression from S1P-mediated lymphocyte sequestration and cytotoxic antibody-drug conjugate myelosuppression.
اقدام لازم
Avoid the combination if possible, or hold siponimod during brentuximab treatment. If used together, monitor neutrophil and lymphocyte counts and infection signs, including neurological symptoms suggesting PML.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Brentuximab vedotin و Siponimod، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Siponimod
- Cladribine + Siponimod منع مصرف
- Fingolimod + Siponimod منع مصرف
- Fluconazole + Siponimod منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Siponimod منع مصرف
- Ponesimod + Siponimod منع مصرف
- Siponimod + Thioridazine منع مصرف
تداخلات دیگر Brentuximab vedotin
پرسش‌های متداول
Can I take Brentuximab vedotin with Siponimod?
MediHelp rates the interaction as major. Brentuximab vedotin and Siponimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brentuximab vedotin can cause neutropenia and serious infections, and it carries a risk of progressive multifocal leukoencephalopathy. Siponimod also carries infection and PML risk, so the combination may increase these concerns.
How serious is the interaction between Brentuximab vedotin and Siponimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or hold siponimod during brentuximab treatment. If used together, monitor neutrophil and lymphocyte counts and infection signs, including neurological symptoms suggesting PML.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
