تداخل‌های دارویی
Bromocriptine + Darunavir
شدت: شدید
Bromocriptine and Darunavir: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise bromocriptine exposure. Higher levels may cause nausea, hypotension, dizziness, somnolence, hallucinations and other dopaminergic adverse effects.
معنای این تداخل به زبان ساده
Bromocriptine and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Darunavir belongs to Anti Virals.
چرا رخ می‌دهد
Inhibition of CYP3A4-mediated metabolism of bromocriptine reduces its clearance.
اقدام لازم
Avoid the combination where possible; if it is necessary, start bromocriptine at a low dose and titrate slowly while monitoring blood pressure and CNS effects. Reduce the bromocriptine dose if adverse effects appear.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Bromocriptine و Darunavir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Bromocriptine
تداخلات دیگر Darunavir
- Alfuzosin + Darunavir منع مصرف
- Avanafil + Darunavir منع مصرف
- Darunavir + Dronedarone منع مصرف
- Darunavir + Eletriptan منع مصرف
- Darunavir + Ergotamine منع مصرف
- Darunavir + Flibanserin منع مصرف
پرسش‌های متداول
Can I take Bromocriptine with Darunavir?
MediHelp rates the interaction as major. Bromocriptine and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise bromocriptine exposure. Higher levels may cause nausea, hypotension, dizziness, somnolence, hallucinations and other dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, start bromocriptine at a low dose and titrate slowly while monitoring blood pressure and CNS effects. Reduce the bromocriptine dose if adverse effects appear.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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