تداخلهای دارویی
Bromocriptine + Elvitegravir / cobicistat / emtricitabine / tenofovir df
شدت: شدید
Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
آخرین بهروزرسانی
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خلاصه
Cobicistat strongly inhibits CYP3A4, the main route of bromocriptine metabolism, so bromocriptine exposure can increase substantially. Effects include hypotension, nausea, somnolence and possible ergot-type vasospasm.
معنای این تداخل به زبان ساده
Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ میدهد
Inhibition of CYP3A4-mediated metabolism of bromocriptine by cobicistat.
اقدام لازم
Avoid the combination if possible or reduce the bromocriptine dose and titrate slowly. Monitor blood pressure and for symptoms of vasospasm or excess dopaminergic effects.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Bromocriptine و Elvitegravir / cobicistat / emtricitabine / tenofovir df، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Bromocriptine
پرسشهای متداول
Can I take Bromocriptine with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat strongly inhibits CYP3A4, the main route of bromocriptine metabolism, so bromocriptine exposure can increase substantially. Effects include hypotension, nausea, somnolence and possible ergot-type vasospasm.
How serious is the interaction between Bromocriptine and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible or reduce the bromocriptine dose and titrate slowly. Monitor blood pressure and for symptoms of vasospasm or excess dopaminergic effects.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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