تداخل‌های دارویی
Buprenorphine + Tranylcypromine
شدت: منع مصرف
Buprenorphine and Tranylcypromine: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining opioids with a nonselective MAO inhibitor has caused severe reactions such as hypotension, hyperthermia, profound sedation, serotonin toxicity and death. Buprenorphine labeling advises against use during or within 14 days of MAOI treatment.
معنای این تداخل به زبان ساده
Buprenorphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Buprenorphine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
چرا رخ می‌دهد
MAO inhibition may potentiate serotonergic and CNS-depressant effects of opioids; the exact mechanism with buprenorphine is not fully defined.
اقدام لازم
Do not use together; separate by at least 14 days after stopping tranylcypromine and choose a non-interacting analgesic.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Buprenorphine و Tranylcypromine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Buprenorphine
- Alvimopan + Buprenorphine منع مصرف
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates منع مصرف
- Buprenorphine + Olanzapine / samidorphan منع مصرف
- Buprenorphine + Phenelzine منع مصرف
- Buprenorphine + Pimozide منع مصرف
- Buprenorphine + Thioridazine منع مصرف
تداخلات دیگر Tranylcypromine
- 5-HTP + Tranylcypromine منع مصرف
- Amitriptyline + Tranylcypromine منع مصرف
- Amoxapine + Tranylcypromine منع مصرف
- Atomoxetine + Tranylcypromine منع مصرف
- Benzphetamine + Tranylcypromine منع مصرف
- Brimonidine + Tranylcypromine منع مصرف
پرسش‌های متداول
Can I take Buprenorphine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Buprenorphine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining opioids with a nonselective MAO inhibitor has caused severe reactions such as hypotension, hyperthermia, profound sedation, serotonin toxicity and death. Buprenorphine labeling advises against use during or within 14 days of MAOI treatment.
How serious is the interaction between Buprenorphine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; separate by at least 14 days after stopping tranylcypromine and choose a non-interacting analgesic.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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