رفتن به محتوا

تداخل‌های دارویی

Bupropion + Isocarboxazid

شدت: منع مصرف

Bupropion and Isocarboxazid: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Isocarboxazid (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

معنای این تداخل به زبان ساده

Bupropion and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity

اقدام لازم

Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Bupropion و Isocarboxazid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Bupropion with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Bupropion and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.

How serious is the interaction between Bupropion and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping isocarboxazid before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.

What other medicines interact with Bupropion?

MediHelp also lists interactions of Bupropion with, for example, Linezolid, Phenelzine, Rasagiline. The full list is on the Bupropion page.

تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp

مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.

مرور از A تا Z · تداخل‌های دارویی

دریافت برنامه ورود