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تداخل‌های دارویی

Apraclonidine + Isocarboxazid

شدت: منع مصرف

Apraclonidine and Isocarboxazid: contraindicated interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.

معنای این تداخل به زبان ساده

Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Apraclonidine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.

سطح شواهد: Low

چرا رخ می‌دهد

Mechanism is not firmly established; MAO inhibition may alter catecholamine metabolism and potentiate the systemic effects of the alpha-2 agonist.

اقدام لازم

Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Apraclonidine و Isocarboxazid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Apraclonidine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Apraclonidine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Apraclonidine labeling lists MAO inhibitors as a contraindication. Theoretically, altered catecholamine handling could cause blood pressure changes, although ophthalmic exposure is small.

How serious is the interaction between Apraclonidine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid apraclonidine in patients on isocarboxazid and use another intraocular pressure-lowering agent. Follow the labeled contraindication.

What other medicines interact with Isocarboxazid?

MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.

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