تداخل‌های دارویی
Cabozantinib + Posaconazole
شدت: شدید
Cabozantinib and Posaconazole: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
معنای این تداخل به زبان ساده
Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Posaconazole belongs to Anti Fungals.
چرا رخ می‌دهد
Strong CYP3A4 inhibition by posaconazole reduces the metabolic clearance of cabozantinib.
اقدام لازم
Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cabozantinib و Posaconazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Posaconazole
- Artemether + Posaconazole منع مصرف
- Avanafil + Posaconazole منع مصرف
- Cobimetinib + Posaconazole منع مصرف
- Conivaptan + Posaconazole منع مصرف
- Dihydroergotamine intranasal + Posaconazole منع مصرف
- Dihydroergotamine + Posaconazole منع مصرف
تداخلات دیگر Cabozantinib
پرسش‌های متداول
Can I take Cabozantinib with Posaconazole?
MediHelp rates the interaction as major. Cabozantinib and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole can raise cabozantinib exposure because cabozantinib is cleared partly by CYP3A4. Higher levels may increase toxicities such as diarrhea, hypertension, hand-foot syndrome and bleeding.
How serious is the interaction between Cabozantinib and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antifungal or other agent without strong CYP3A4 inhibition. If it cannot be avoided, lower the cabozantinib dose per labeling, monitor for adverse effects, and restore the prior dose a few days after stopping posaconazole.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
