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تداخل‌های دارویی

Caplacizumab + Dalteparin

شدت: شدید

Caplacizumab and Dalteparin: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and causes bleeding on its own. Adding a low molecular weight heparin increases the likelihood of mucosal, surgical-site and other hemorrhage.

معنای این تداخل به زبان ساده

Caplacizumab and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Caplacizumab belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive hemostatic impairment from antiplatelet-adhesion effect of caplacizumab plus factor Xa inhibition by dalteparin.

اقدام لازم

Use together only when clearly needed and monitor closely for bleeding signs and hemoglobin; withhold caplacizumab and seek urgent assessment if clinically significant bleeding occurs.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Caplacizumab و Dalteparin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Caplacizumab with Dalteparin?

MediHelp rates the interaction as major. Caplacizumab and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab inhibits von Willebrand factor-mediated platelet adhesion and causes bleeding on its own. Adding a low molecular weight heparin increases the likelihood of mucosal, surgical-site and other hemorrhage.

How serious is the interaction between Caplacizumab and Dalteparin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when clearly needed and monitor closely for bleeding signs and hemoglobin; withhold caplacizumab and seek urgent assessment if clinically significant bleeding occurs.

What other medicines interact with Dalteparin?

MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.

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