تداخل‌های دارویی
Carbidopa-entacapone-levodopa + Phenelzine
شدت: منع مصرف
Carbidopa-entacapone-levodopa and Phenelzine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (phenelzine) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
معنای این تداخل به زبان ساده
Carbidopa-entacapone-levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
چرا رخ می‌دهد
Non-selective MAO inhibition prevents degradation of levodopa-derived catecholamines with additional COMT inhibition
اقدام لازم
Do not give together. Wait at least 14 days after stopping phenelzine before starting the other drug; carbidopa reduces but does not eliminate the risk.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Carbidopa-entacapone-levodopa و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid منع مصرف
- Carbidopa-entacapone-levodopa + Selegiline transdermal منع مصرف
- Carbidopa-entacapone-levodopa + Tranylcypromine منع مصرف
- Amisulpride + Carbidopa-entacapone-levodopa شدید
- Asenapine transdermal + Carbidopa-entacapone-levodopa شدید
- Carbidopa-entacapone-levodopa + Chlorpromazine شدید
تداخلات دیگر Phenelzine
- 5-HTP + Phenelzine منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Amoxapine + Phenelzine منع مصرف
- Atomoxetine + Phenelzine منع مصرف
- Benzphetamine + Phenelzine منع مصرف
- Brimonidine + Phenelzine منع مصرف
پرسش‌های متداول
Can I take Carbidopa-entacapone-levodopa with Phenelzine?
MediHelp rates the interaction as contraindicated. Carbidopa-entacapone-levodopa and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and noradrenaline, and a non-selective MAO inhibitor (phenelzine) prevents their breakdown so the amines accumulate. Entacapone further impairs catecholamine breakdown through COMT inhibition. Severe hypertension, flushing, headache and hyperpyrexia may follow.
How serious is the interaction between Carbidopa-entacapone-levodopa and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. Wait at least 14 days after stopping phenelzine before starting the other drug; carbidopa reduces but does not eliminate the risk.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Selegiline transdermal, Tranylcypromine. The full list is on the Carbidopa-entacapone-levodopa page.
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