تداخل‌های دارویی
Carbimazole + Rosuvastatin
شدت: متوسط
Carbimazole and Rosuvastatin: moderate interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
معنای این تداخل به زبان ساده
Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbimazole belongs to Endocrine; Rosuvastatin belongs to Cardiovascular.
چرا رخ می‌دهد
Pharmacodynamic and indirect: drug-induced hypothyroidism predisposes to statin myotoxicity. No direct CYP or transporter interaction is expected.
اقدام لازم
Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Carbimazole و Rosuvastatin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
- Crestor (rosuvastatin calcium) Prescribing Information - Warnings and Precautions: Myopathy and Rhabdomyolysis — FDA Label
- Neo-Mercazole (carbimazole) Summary of Product Characteristics — EMA SmPC
تداخلات دیگر Carbimazole
- Carbimazole + Tiratricol متوسط
تداخلات دیگر Rosuvastatin
پرسش‌های متداول
Can I take Carbimazole with Rosuvastatin?
MediHelp rates the interaction as moderate. Carbimazole and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbimazole treats hyperthyroidism and can overshoot into hypothyroidism if the dose is excessive. Hypothyroidism is a recognised risk factor for statin-associated myopathy and rhabdomyolysis, so muscle toxicity from rosuvastatin may be more likely during periods of low thyroid function. The interaction is indirect and depends on thyroid status.
How serious is the interaction between Carbimazole and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check thyroid function before starting or increasing rosuvastatin and aim for euthyroidism. Monitor thyroid function regularly after carbimazole dose changes and adjust carbimazole if TSH rises.
What other medicines interact with Carbimazole?
MediHelp also lists interactions of Carbimazole with, for example, Tiratricol. The full list is on the Carbimazole page.
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