تداخل‌های دارویی
Carboplatin + Olaparib
شدت: شدید
Carboplatin and Olaparib: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
معنای این تداخل به زبان ساده
Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Olaparib belongs to Oncology.
چرا رخ می‌دهد
Additive myelosuppression from a PARP inhibitor and a DNA-damaging platinum agent.
اقدام لازم
Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Carboplatin و Olaparib، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Carboplatin
تداخلات دیگر Olaparib
پرسش‌های متداول
Can I take Carboplatin with Olaparib?
MediHelp rates the interaction as major. Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
How serious is the interaction between Carboplatin and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
